Clinical Editor's comments (September 2017)
Dr Hayley Willacy would like to make you aware that people with moderate to severe plaque psoriasis can now receive dimethyl fumarate (Skilarence®) as a licensed oral treatment option for those needing systemic therapy [ 19 ] . It can be prescribed as first-line induction therapy and long-term maintenance treatment. Dimethyl fumarate as Fumaderm® is already used as an unlicensed product in the UK. The anti-inflammatory and immunomodulating effects of dimethyl fumarate are not fully understood but are thought to involve a shift in T helper cells from the Th1 and Th17 phenotypes to the Th2 phenotype, with a resultant decrease in the production of inflammatory cytokines and inhibition of keratinocyte proliferation.