Being the potent steroid that it is, Epistane does come with a list of side effects. Epistane is a methylated steroid, and while it causes less liver stress than other compounds like Superdrol, liver stress is still an issue so it would be wise to use some type of liver support with this compound. Though the anti-estrogen effects of Epistane can have positive effects, there is also the possibility of “dry” or achy joints. Some users have had success in alleviating this issue by adding in a moderate dose of DHEA while on cycle. Like many other steroids, Epistane is known to cause painful cramping and pumps, particularly in the lower back and calves.