Effective options for stress ulcer prophylaxis include PPIs, H 2 antagonists, antacids, and sucralfate (Carafate). No medication has been shown to be superior to another. Although the optimal duration of prophylaxis is not known, most experts suggest continuing therapy while the patient is in the ICU, when bleeding risk is highest. However, many patients continue to receive prophylaxis inappropriately when they are transferred to general medical units and continue therapy after discharge without clear medical indications. 31 To minimize adverse outcomes, physicians should discontinue PPIs in patients when they are discharged from the ICU if there are no other indications for therapy.
My neuro surgeon (NS) put me on Cipro and Keppra to start my recovery at home. Within days I developed severe tendonitis and a visit to my GP revealed that it is a classic effect of Cipro and so she switched that med to extra strength Tylenol and the problem went away. Then I developed significantly swollen legs and upon research and subsequent discussion with my NS he switched me to Dilantin; now I don't sleep very well and still have the swelling! My online research also tells me that Dilantin should not be taken with Prednisone which I take at 10mg daily for my Peripheral Neuropathy.