Peliosis hepatis anabolic steroids

      Anabolic-androgenic steroids ('anabolic steroids') are structurally related to testosterone.

The suggested dosage for androgens varies depending on the age, and diagnosis of the individual patient. Dosage is adjusted according to the patient’s response and the appearance of adverse reactions. The dosage guideline for the testosterone pellets for replacement therapy in androgen-deficient males is 150mg to 450mg subcutaneously every 3 to 6 months. Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower doses initially, gradually increasing the dose as puberty progresses, with or without a decrease in maintenance levels. Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose.

Anabolic steroids are a type of substances whose chemical composition is similar to hormones such as testosterone. These substances are used by many sports persons and body builders to improve their fitness, and to increase their stamina and strength. In many sports, use of such substances is therefore illegal, because they are deemed to give undue advantage to their users. Apart from their illegality in many sports, there still are many negative side effects of anabolic steroids. Here we will discuss the 4 main disadvantages of using anabolic steroids.

Two morphologic patterns of hepatic peliosis were described by Yanoff and Rawson. [7] In the phlebectatic type, the blood-filled spaces are lined with endothelium and are associated with aneurysmal dilatation of the central vein; in the parenchymal type, the spaces have no endothelial lining and they usually are associated with haemorrhagic parenchymal necrosis. Some consider both patterns to be one process, initiated by focal necrosis of liver parenchyma, observed in parenchymal type, progressing into formation of fibrous wall and endothelial lining around haemorrhage of phlebectatic type. Fibrosis , cirrhosis , regenerative nodules, and tumours may also be seen.

Peliosis hepatis anabolic steroids

peliosis hepatis anabolic steroids

Two morphologic patterns of hepatic peliosis were described by Yanoff and Rawson. [7] In the phlebectatic type, the blood-filled spaces are lined with endothelium and are associated with aneurysmal dilatation of the central vein; in the parenchymal type, the spaces have no endothelial lining and they usually are associated with haemorrhagic parenchymal necrosis. Some consider both patterns to be one process, initiated by focal necrosis of liver parenchyma, observed in parenchymal type, progressing into formation of fibrous wall and endothelial lining around haemorrhage of phlebectatic type. Fibrosis , cirrhosis , regenerative nodules, and tumours may also be seen.

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