A recent study discovered the application of certain moisturizers increases the incidence of skin cancer in high-risk mice, but these animals were subjected to UVB radiation in high doses over a long period of time prior to application of moisturizers.  Four popular moisturizers were tested, providing the same result. It is not yet known if the same applies to humans. A fifth moisturizer, specially prepared without mineral oil and sodium lauryl sulphate , had no such effect.  The researchers asked Johnson & Johnson to produce this cream for the study, which the pharmaceutical company later patented. [ citation needed ]
AB - The management of chronic hand eczema is usually difficult. The aim of this open-label study is to assess the effectiveness and 'steroid-sparing' activity of a barrier cream containing polyvinylpyrrolidone in patients with chronic hand eczema. Rescue treatment with topical corticosteroids (TCs) was permitted in the event of eczema worsening, whereas preventive measures were maintained unchanged with respect to those adopted by patients in the past. Among the 207 participants, the main diagnosis was irritant contact dermatitis, followed by allergic contact dermatitis and atopic dermatitis. Nearly half of the patients (49%) applied the barrier cream once or twice a day, while the remaining patients used it three or more times per day. Regardless of rescue therapy with TCs, regular use of the barrier cream caused a progressive significant improvement of eczema severity, as indicated by dermatologists' and patients' assessments. A significant reduction in the amount of the TC applied in the last 3 months and in the number of TC treatment days during the previous 4 weeks was found at the end of 12-week treatment with the barrier cream as compared with baseline. The product was also well-tolerated and accepted by the majority of patients. The results of this study suggest that a barrier cream containing polyvinylpyrrolidone can represent a useful tool in the management of chronic hand eczema and may show steroid-sparing effects.